Since we are enrolling only those with MCI, we anticipate that most participants will have decision capacity In those who lack decision capacity, a study surrogate who can sign on their behalf will be required.Inability to perform the study procedures.Minimal Functional limitation as reflected by the Functional Assessment Questionnaire (FAQ)≤7.Executive dysfunction: A performance at the 10th percentile or below on at least one of four screening tests for executive function: Trail Making Test, Part B (TMT-B), modified Stroop interference, Digit Span and Digit Sequencing, and Letter fluency.The Montreal Cognitive Assessment (MoCA) score less than or equal to 26.Hypertension: SBP≥140 mm Hg or DBP≥ 90 mm or receiving antihypertensive medications.Įxecutive MCI will be defined using these criteria:.Participants will be seen at 3, 6 and 12 months afterwards. Description of intervention, follow-up, and duration of study: Eligible participants will undergo randomization into 2 groups and will be seen frequently until their blood pressure is controlled (Endpoints to be measured:Our measures include cognitive function, cerebral perfusion and reserve, markers of vascular brain damage, atherosclerosis, stiffness, vascular inflammation and endothelial function.Our target population is subjects: 55 years or older with hypertension and Executive Mild Cognitive Impairment.
#Backward digit span versus forward digit span trial#
Study methodology:This is a double blind randomized clinical trial that will be conducted in 140 individuals (70 in the candesartan group, 70 in the lisinopril group).The study also intends to identify potential underlying mechanisms related to vascular structure and function, including atherosclerosis, vascular inflammation, vascular stiffness, and endothelial progenitor cells, by which candesartan may affect the cognitive and cerebrovascular outcomes. Objectives or purpose: The aims of this study are to investigate the effects of candesartan on executive function decline and on changes in cerebral perfusion, cerebrovascular reserve and microvascular brain injury.To date, no specific treatment is available for this pattern of mild cognitive impairment related to hypertension. Hypertension is associated with cognitive impairment even in the absence of clinical dementia.Why Should I Register and Submit Results?.
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